Synovium extra cellular matrices seeded with transduced mesenchymal stem cells stimulate chondrocyte maturation in vitro and cartilage healing in clinically-induced rat-knee lesions in vivo.
Osteoarthritis (OA) is a progressive disease associated with cartilage injury and its inherently limited repair capability.Synovium-based cellular constructs (sConstructs) are proposed as possible treatments.Equine sConstructs were produced from decellularized synovium-based extracellular matrix scaffolds (sECM) seeded with synovium-derived mesench